We are excited to announce the release of our latest paper titled, “Lung Cancer Volume Doubling Time by Computed Tomography: A Systematic Review and Meta-analysis.” This comprehensive study aims to provide an overview of primary lung cancer growth rate, quantified by volume doubling time (VDT) through computed tomography (CT) measurement.
Through a systematic review and meta-analysis of existing literature, this paper demonstrated that the pooled mean VDT of solid lung cancer was approximately 207 days, demonstrating significant variability in histology while remaining under the 400-day referral threshold. Key predictors of growth rate include histology, size, solidity, and smoking history, which are essential for tailoring early intervention strategies.
📊 Highlights 📊
- Systematic review and meta-analysis of 33 studies with 3959 lung cancer patients
- Pooled VDT for solid, part-solid, and nonsolid lung cancer: 207, 536, and 669 days
- Pooled VDT for adeno, squamous, and small cell lung cancer: 223, 140, and 73 days
- Indolent lung cancer (VDT>400d or <0) in 34.9% of cases, 68.9% in adenocarcinoma
- Growth rates related to histology, size, solidity, TNM stage, and smoking history
Read the full paper here
